An observational assessment of Arthramid® : A novel intra-articular injection and its relationship with veterinary physiotherapy on patient outcomes in Labrador Retrievers with elbow osteoarthritis.

Elbow Osteoarthritis: A Pilot Study

Design: Non-blinded prospective observational clinical study
Method: 20 client-owned Labrador Retriever dogs with evidence of moderate to severe elbow OA (using radiography, computer tomography, and arthroscopy) and clinically lame were enrolled
Treatment: 1 ml of 2.5% iPAAG was injected into the worst elbow joint via intra-articular injection

Response to treatment was evaluated by the following at 4 weeks:

• Gait4Dog gait analysis
• HALO goniometry
• AimOA
• Clinical findings

Results:

• In 75% of patients 2.5% iPAAG significantly improved lameness during the first 4 weeks
  Gait Analysis showed significant improvement in weight-bearing pressure between baseline and
  week 4 (p = 0.007)
• Elbow Flexion – HALO (p = 0.04)
• Pain Parameters – AIM OA Sys (p = 0.02)
• Limb Function – AIM OA Sys (p = 0.001)*

Conclusions: A 1mL injection of 2.5% iPAAG into a moderate to severe arthritic elbow does have a statistically significant positive effect on physical improvement in elbow osteoarthritis, including reducing degree of lameness, reduced pain scores and improvement in elbow flexion.

*A p value of less than 0.05 is considered clinically significant

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