Synovial Transcriptomic Response To Intra-Articular 2.5% Polyacrylamide Hydrogel Therapy In Experimentally Induced Equine Osteoarthritis

Presented at ICRS – 18th World Congress, Boston, MA. 11-14th October 2025.

Lynn Pezzanite; Colorado State University, Fort Collins, CO/ US.

Background:

Osteoarthritis (OA) represents one of the most common conditions treated by equine practitioners.

Despite this high prevalence, no approved pharmacological intervention, biological therapy, or procedure prevents or reverses progressive destruction of degenerative joints.

Intra-articular injectable 2.5% polyacrylamide hydrogel (iPAAG®), which consists of biocompatible non-degradable synthetic polymers, have been introduced with reported clinical efficacy.

However, their potential mechanisms of action have not been investigated