ArthramidVet® for Canines

Next Generation Joint Treatment

  • 2.5% cross-linked polyacrylamide hydrogel
  • Long-lasting – non-absorbable
  • 82.5% successful resolution of joint lameness out to 24 month
  • Integrates into the joint tissue providing shock absorption to the joint
  • Safe, biocompatible, non-toxic and neuro-innocuous
  • ArthramidVet is indicated for the management of non-infectious causes of joint disease in horses and dogs.

Contact your veterinarian to discuss the benefits of ArthramidVet and how it may help treat osteoarthritis in your dog.

Proven Science. Proven Results.

ArthramidVet® is a non-resorbable, injectable, transparent, hydrophilic gel, for intra-articular administration in dogs only.

ArthramidVet® consists of a backbone of cross-linked polyacrylamide, with water molecules loosely bound to the polyer matrix. Nominal proportions of the ArthramidVet® gel are 2.5% cross-linked polycrylamide and 97.5% non-pyrogenic water for injection, ArthramidVet® is biocompatible and non-biodegradable and is sterilized by moist heat.

ArthramidVet® is supplied in a pre-filled, sterile, 1 mL syringe sealed with a luer lock fitting. It is intended to be injected with a sterile 21-23-gauge hypodermic needle.

Mode of Action

Not all polyacrylamide hydrogels are the same.  Polyacrylamide hydrogel products, although often considered equal, have clear differences in composition, manufacturing quality and injection techniques as well as their ability to interact with surrounding tissues. These characteristics determine the safety and effectiveness of each hydrogel.

Upon injection into joints, ArthramidVet®, a uniquely cross-linked 2.5% polyacrylamide hydrogel, adheres to the synovial lining through its ability to exchange water molecules. Over a period of 14 days, the gel becomes integrated into the synovial lining and its immediate surrounding tissue of the inner capsule by a combination of cell migration and vessel ingrowth forming a thick, cushion-like membrane consisting of vessel integrated gel covered by a new and hypercellular synovial cell lining.

Unlike other hydrogels, ArthramidVet® becomes fully integrated into the surrounding tissue (rather than encapsulated) and is therefore long-lasting. ArthramidVet® does not elicit a foreign body reaction or harbor infection. ArthramidVet® is non-pyrogenic, neuro innocuous and contains no heavy metals.

Dosage Recommendations

The following dosage recommendations have been made, based on observed clinical responses to administration:

Large Joint | Shoulder, Elbow, Hip and Stifle
  • Size of Dog: Less than 20kg | Dose to be administered: 0.5mL
  • Size of Dog: More than 20kg | Dose to be administered: 1mL
Medium Joint | Carpus and Tarsus
  • Size of Dog: Less than 20kg | Dose to be administered: 0.25 – 0.5mL
  • Size of Dog: More than 20kg | Dose to be administered: 0.5 – 1mL
Small Joint | Interphalangeal Joint
  • All Sizes of Dogs | Dose to be administered: 0.01 – 0.1mL

A single injection of the advised volume above is considered adequate administration to achieve the effect.
Concurrent treatment of multiple joints can be performed

Post-injection instructions

A cold pack can be applied to the injection site in case of edema. Local or systemic corticosteroids should not be administered to the animal within two weeks of injection of ArthramidVet® since this may mask a possible infection.

The animal should be rested for 48 hours after treatment and then be on a restricted exercise schedule for 4 weeks post-injection. After this period, the animal should gradually return to normal exercise levels.

Some animals can develop pain within the first few hours post-administration. In addition, there is also a slight risk of hematoma and mild edema at the site of injection. Within 1-2 weeks after treatment, there is a slight risk that the animal may develop transient edema and tenderness at the treatment site as the tissue integration is occurring. If not caused by infection, these reactions are self-limiting and will resolve within a couple of weeks. Non-steroidal anti-inflammatory drugs (NSAIDs) can be administered for pain relief and to reduce swelling.

Allergic reactions to ArthramidVet® have not been observed.

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