Mode of Action
Not all polyacrylamide hydrogels are the same. Polyacrylamide hydrogel products, although often considered equal, have clear differences in composition, manufacturing quality and injection techniques as well as their ability to interact with surrounding tissues. These characteristics determine the safety and effectiveness of each hydrogel.
Upon injection into joints, ArthramidVet, a uniquely cross-linked 2.5% polyacrylamide hydrogel, adheres to the synovial lining through its ability to exchange water molecules. Over a period of 14 days, the gel becomes integrated into the synovial lining and its immediate surrounding tissue of the inner capsule by a combination of cell migration and vessel ingrowth forming a thick, cushion-like membrane consisting of vessel integrated gel covered by a new and hypercellular synovial cell lining.
Unlike other hydrogels, ArthramidVet becomes fully integrated into the surrounding tissue (rather than encapsulated) and is therefore long-lasting. ArthramidVet does not elicit a foreign body reaction or harbor infection. ArthramidVet is non-pyrogenic, neuro innocuous and contains no heavy metals.