Veterinarians: Get your copy of our 24 page white paper today, covering Treatment of Joint Lameness, Pathophysiology, Manufacturing, Mechanism of Action, Clinical Safety and Putting it into Practice.
Arthramid
Clinical Studies
PROVEN SCIENCE.
PROVEN RESULTS.
PROVEN RESULTS.
Discover the Science Behind Arthramid® 2.5% iPAAG
Arthramid is trusted by veterinarians around the world to treat joint lameness in animals, including horses and dogs. Backed by multiple published studies from leading institutions and with thousands of successful treatments across a range of species and disciplines, Arthramid is a proven, safe, and effective option for managing osteoarthritis and joint-related conditions in veterinary medicine.
Clinical Studies: Research OA Papers
2025
October 2025
Owner-Reported Safety and Efficacy of 2.5% Polyacrylamide Hydrogel (iPAAG) Intra-Articular Injections in Dogs with Osteoarthritis
Jennifer A. Barnhard BVetMed, MS, Ashley A. Tringali BS, Nina C. Caldwell BS, Kathryn R. Webb BS, David Levine PT, DPT, MPH, PhD, Arielle Pechette Markley DVM, DACVSMR, Abigail Shoben PhD, Megan M. Green DVM, and Matthew W. Brunke DVM, DACVSMR.
This study evaluates owner-reported safety and efficacy of 2.5% Polyacrylamide Hydrogel (2.5% iPAAG®) intra-articular injections in dogs diagnosed with osteoarthritis (OA).
2019
July 2019
Use of a 2.5% Cross-Linked Polyacrylamide Hydrogel in the Management of Joint Lameness in a Population of Flat Racing Thoroughbreds: A Pilot Study
de Clifford, L.D., Lowe, J.N., McKellar, C.D., Bolwell, C., and David, F. Journal of Equine Veterinary Science. 2019
Osteoarthritis (OA) is cited as the most important musculoskeletal disorder in both humans and horses [1]. Several medications have been evaluated in the treatment of horses with OA, including nonsteroidal anti-inflammatory drugs (NSAIDs),
2017
September 2017
Initial Estimates of Efficacy of Intra-Articular 2.5% Polyacrylamide Hydrogel for the Treatment of Knee Osteoarthritis: An Observational Proof-of-Concept Study
Henrikson, M., Overgaard, A., and Bliddal, H. Arthritis Rheumatol. 2017;
There is a draught of available effective treatments of knee osteoarthritis (OA) and tests of new therapies are needed. Polyacrylamide hydrogel (PAAG) is a non-toxic, non-degradable synthetic product, used for years in the augmentation of soft tissues.
2016
July 2016
Synovial incorporation of polyacrylamide hydrogel after injection into normal and osteoarthritic animal joints
Christensen, L., Illigen, K.E., Hansen, M., Sarvaa, R., and Conogham, P.G. (2016).
Polyacrylamide hydrogel (PAAG) is a non-toxic, non-degradable synthetic product, used for years in the augmentation of soft tissues. Preliminary results in animals and humans have suggested long-lasting beneficial effects on symptoms of osteoarthritis (OA).
July 2016
Intra-articular polyacrylamide hydrogel for the treatment of 20 horses with non-responsive osteoarthritis of the interphalangeal joints: a prospective study
Bathe, A.P., Read, R.M., and Briggs, C. (2016).
Our objective was to determine the effect of an omega-3 fatty acid rich diet (JM) with and without rehabilitation therapy (R) postoperatively on radiographic bone healing, radiographic osteoarthritis (OA) progression,
Arthramid White Papers
CANINE WHITE PAPER
Veterinarians: Get your copy of our 21 page white paper today, covering Treatment of Joint Lameness, Pathophysiology, Manufacturing, Mechanism of Action, Clinical Safety and Putting it into Practice.
Testimonials
Dr. Dan Carter
COUNTRYSIDE VETERINARY HOSPITAL - COVINGTON, GA
“Arthramid is a game changer for all equine athletes. It all starts in the synovium with synovitis and capsulitis, before we get to osteoarthritis. I routinely tell my horse owners, ‘save the synovium, save the joint’.”
Dr. Vern Dryden
BUR OAK SPORTS MEDICINE & LAMENESS, LEXINGTON, KY
“It’s given me another tool in my arsenal to effectively manage all stages of equine osteoarthritis, especially those horses with equine metabolic disease.”
Dr Marc Koene
TIERKLINIK LÜSCHE GMBH EQUINE HOSPITAL – NORTHER GERMANY
"We have injected over a thousand horses and have found it to be very safe. It has been a major game-changer in the way we treat OA in our patients.”
Dr Charley McColough
PALM BEACH EQUINE - WELLINGTON, FL
"By incorporating Arthramid into my practice, I’m able to use far fewer steroids while still achieving excellent results, which gives me greater peace of mind for the long-term well-being of the horses under my care."
Dr Bob Peters
MCKINLAY & PETERS EQUINE HOSPITAL - NEWMAN LAKE, WA
"In my opinion, it is efficacious, long-lasting and lower risk to cartilage than many alternatives."
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