Comparison of 2.5% iPAAG versus Triamcinolone (TA) and Hyaluronic Acid (HA) in a double-blinded positive control study JEVS 107 (2021) in horses showing 83.3% successful resolution of lameness at 6 weeks in Arthramid treated group.

Arthramid, the Right Solution for Equine Joint Health

Arthramid is a patented 2.5% injectable polyacrylamide hydrogel (iPAAG). Administered through intra-articular joint injection, it integrates into the synovium of the joint, improving function and resolving lameness.

Arthramid goes beyond conventional therapies, employing dynamic bio-scaffold technology to safely and sustainably manage osteoarthritis.

  • Increased load transfer capacity through the joint capsule
  • Reduced effusion and decreased stiffness
  • Over 80% of patients remain lame-free after one injection
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Joint After Administration of Arthramid

The Synovial Membrane Matters

Discover the role of the synovium

The synovium—the inner lining of the joint capsule—produces joint fluid essential for cushioning, reducing friction, and nourishing cartilage. When damaged, synovial cells produce lower-quality fluid, leading to inflammation, synovitis, capsulitis, and osteoarthritis (OA).

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How Arthramid Works

2.5% iPAAG targets the synovial membrane directly. Once injected, it integrates into the synovial membrane within approximately two weeks.

KEY POINTS
  • Bio-mechanical support: Reinforces the synovial membrane.
  • Restored elasticity and strength: Reduces stiffness and fibrosis.
  • Improved joint fluid quality: Modulates the inflammatory response, breaking the OA cycle.

By restoring joint homeostasis, Arthramid delivers long-term benefits to horses and their owners.

Arthramid Mechanism Of Action

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Key Features of Arthramid

  • Patented 2.5% iPAAG technology: Effective for joint lameness in early and late stages of OA.
  • Proven efficacy: Backed by clinical trials across multiple equine disciplines.
  • Bio-scaffold action: Reduces pain and lameness.
  • Long-lasting results: Sustained soundness and lame-free outcomes.
  • Safe multi-joint treatment: Treat multiple joints in the same animal.
  • Extensive research: Over 20 years of studies in horses and humans, with ongoing R&D from Contura.
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Frequently Asked Questions

What are the right cases for Arthramid?

Arthramid can be used in any synovial joint showing signs of osteoarthritis, including
pain, swelling, reduced range of motion, or lameness confirmed by diagnostic imaging
like X-rays, ultrasound, or MRI. It is effective in both early stages (e.g., synovitis and
capsular stiffness) and advanced or chronic cases of OA.

Before injection, it is important to review the animal’s medical history, including any
signs of infection, current medications, recent surgeries, or fractures, to ensure safe
and appropriate use.

How is Arthramid administered?

Arthramid comes in prefilled sterile 1 mL syringes, sealed via Luer lock fitting. Arthramid should be administered via a sterile 18-23g needle using aseptic injection technique protocols.

Post-treatment recommendations

After treatment, rest the horse for 48 hours and plan a reduced-impact workload for up to 2 weeks to allow full integration of the 2.5% iPAAG. A follow-up examination at 4 to 6 weeks is advised to assess the response, with a top-up dose administered if needed.
Horses often show gradual improvement in lameness within the first week, with continued progress over the following weeks. Repeat doses of Arthramid can be safely given every 6 to 12 months if required and clinically indicated.

Dosage recommendations

Arthramid is for intra-articular injection only. The dose may vary depending on the severity of disease, the size of the joint and the duration of clinical signs. The following recommendations have been made based on observed clinical responses to treatment.

Distal Interphalangeal: 1-2mL
Proximal Interphalangeal: 1 mL
Metacarpo/Tarso-phalangeal: 2 mL
Carpus: 2-3mL
Tarsometatarsal/ Distal Intertarsal: 1 mL
Tarsocrural: 2-3 mL
Shoulder: 2-3 mL
Stifles: 2-3 mL per compartment

How is Arthramid stored?

Arthramid must be stored protected from direct sunlight at room temperature (below 25 degrees Celsius). Do not freeze. Do not store unsealed syringes for later use. Arthramid has a 3-year shelf life from date of manufacture; always check package expiration date before use.

Explore Additional Arthramid Videos

Arthramid Insights from Dr. Jason Lowe
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Clinical Application of Arthramid
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